Professor Valenzuela is a pioneer of healthy brain ageing, his contributions spanning basic science, digital and biomedical innovation, neuroimaging, clinical trials, public health and scientific communication with the general public.
He is an advisor to the World Health Organization, Founder and Chief Scientific Officer of Skin2Neuron, and Visiting Professor at the School of Psychiatry and Centre for Healthy Brain Ageing, University of New South Wales in Sydney, Australia.
He has a career interest in Cognitive Reserve, contributing mechanistic and epidemiologic insights as well as one of the most widely-used and translated assessment tools (Lifetime of Experiences Questionnaire). He developed the Brain Training System and invented the LOGOS automated memory technology for Maintain Your Brain, the world’s largest dementia prevention trial. Currently, he is pioneering a new field of voice-based biomarkers of dementia risk, and contributes to international health policy including for the WHO Integrated Care for Older People (ICOPE) implementation program.
He is also primary inventor of new technology for the manufacture of neurons from the human hair follicle, and led preclinical studies over a 10-year period that found these cells may be effective for treating neuronal and synaptic loss. On the basis of this intellectual property he founded Skin2Neuron, a new Australian biotech company that is taking this concept forward to human clinical trial for the first time in 2027.
Professor Valenzuela has been honoured with several awards, including the Australian Museum’s Eureka Prize for Medicine and a National Health and Medical Research Council of Australia Excellence Award. He is the author of a popular science book (Maintain Your Brain), co-developer of two apps (BrainyApp, Help!App) and published over 100 peer-reviewed scientific papers cited more than 15,000 times.
Talking Points
Brain Plasticity: What Is It and How Can We Harness It?
Norman Doidge (The Brain that Changes Itself) introduced the world to the concept of brain plasticity, but what does it really mean? In this talk, leading neuroscientist and Associate Professor Michael Valenzuela will explain the nuts and bolts of neuroplasticity, giving examples from his cutting edge research. He will show how exercise triggers molecular changes in the brain within a matter of hours, synaptic networks begin to adapt over days and chunks of the brain physically expand after weeks. But what training is best for the brain? Valenzuela will share his ideas on how to turn science into practice, introducing the concepts of brain hygiene, brain fitness and brain gyms.
Brain Plasticity: What Is It and How Can We Harness It?
Retirement is Neurotoxic and Needs Reinvention
Mental inactivity is the number one modifiable risk factor for dementia worldwide. In western countries, this translates to mental laziness. We can all understand how physical inactivity can lead to weak muscles, poor fitness and susceptibility to injury; the science of neuroplasticity is finding that similar principles apply to the brain. More precisely, when we decide to stop working and what we then decide to do with our brains has a material effect on our risk of developing dementia. In this presentation, Valenzuela will unpack these ideas and argue for the reinvention of retirement, a 20th-century construct that is past its use-by date. But what will the new retirement look like? Join the conversation.
Retirement is Neurotoxic and Needs Reinvention
From Skin Cells to Neurons: The Stem Cell Revolution
Yamanaka received the Nobel Prize for medicine in 2012 for his discovery of induced pluripotential stem cells (iPS cells). What he found was that by upregulating just four key genes, any cell could be tricked into behaving like an embryonic cell, that is, the primordial cell that develops into a whole organism. So now your own small skin sample can theoretically produce new kidney tissue, bone marrow, heart muscle or brain cells. What does this mean for the future of medicine? Valenzuela will share insights from his own stem cell research to show this has enormous potential but also many road blocks. Deeper questions about the nature of human identity and the potential to create chimeras new hybrid species will be discussed.
From Skin Cells to Neurons: The Stem Cell Revolution
Dogs: The Miracle Animal
A talk for dog lovers or perhaps a neuroscientist's ode to his favourite animal. Dogs are exceptional animals in more than one sense. They contain the animal kingdom's most plastic DNA, having evolved through the unnatural selection process of human breeding to possess the most extreme physical variability of any species. They are also the single animal to scan the human eye zone naturally searching eternally for a glimpse of insight into our souls. Yet it is their brain that is the most extraordinary. Valenzuela's team have found that the dog brain has structural features of both rodents and humans, making them truly the bridging species par excellence. Like their human masters, dogs are getting fatter, becoming diabetic and living longer. Like humans, a large proportion of dogs succumb to canine dementia (a syndrome defined for the first time by Valenzuela) as they get older. Dogs may hold the secret to how dementia develops and provide a new and completely naturalistic way of trialling new treatments. Yet another example of how they are trying to look after us, God bless 'em.
Dogs: The Miracle Animal
